My laboratory focuses on systematic characterization of genetic variants to understand the regulation of cell
metabolism; metabolic biology to control cellular disease phenotypes with the major focus of metabolic
diseases suggested by human genetics; molecular mechanisms to determine roles of the microbiome in health and
disease; and the molecular mechanisms uncovering patterns of human and microbial pathway regulation during
disease and treatment.
In my laboratory, we develop a unique research program studying the interactions between the mammalian host
and its microbiome, and uncovering their effects on health and disease with the major focus of metabolic
diseases. We utilize a variety of methodologies, which encompass in-vitro experiments, animal models,
preclinical animal testing, advanced metabolic profiling and genomic data analyses to uncover their
functional crosstalk in human health and disease. Eventually, we will translate our findings from the bench
to bedside by conducting human clinical studies.