Ardisiacrispin B, a natural triterpenoid saponins, suppresses dextran sulfate sodium-induced inflammatory bowel disease by rebalancing the gut microbiota and Th17/Treg of mice, 2026

Ruan Y, Chen Y, Peng W, Duan Y, Luo Q, Ullah H, Majid M, Wong HLX, Xie Y, Dai W, Hu X. Inflammopharmacology. 2026 Jan;34(1):597-617.

Gut bacteria that produce fatty acid ethanolamides alleviate diarrhea-predominant IBS with insulin resistance, 2026

Xu S, Lyu J, Bao G, Zheng P, Li Y, Ning Z, Li B, Zhuang M, Wong HK, Wang M, Zeng Y, Zheng Y, Luo J, Liu Q, Zhang L, Lin C, Xiao H, Yuan CS, Wong HLX, Bian Z. Cell Host Microbe. 2026 Jul 8;34(7):1350-1366.e8.

H2BE113K mutation promotes breast cancer metastasis through modulating chromatin dynamics, 2026

Hu S, Liu J, Zhou J, Chen J, Qin T, Wan YCE, Zhu X, Wang D, Shao C, Chen Y, Wang X, Han J, Wong HLX, Weiss RS, Jin H, Chen M, Li Q, Saunthararajah Y, Gan H, Chan KM. Sci Adv. 2026 Jul 10;12(28):eadx4982.

15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer, 2025

Chen M, Chen B, He Q, Xiao S, Li B, Ye Y, Zhang H, Wong HLX, Ji Y, Su T, Kwan HY. J Transl Med. 2025 Dec;23(1):1335.

Butyrate-producing commensal bacteria mediates the efficacy of herbal medicine JCM-16021 on abdominal pain in diarrhea-predominant irritable bowel syndrome: a randomized clinical trial, 2025

Zhai L, Zheng Y, Lo CW, Xu S, Jiang X, Liu Q, Ching JY, Ning Z, Bao G, Yang W, Zhang Q, Cheng CW, Lam WC, Chan KL, Zhang X, Lam PY, Wu XY, Zhong LLD, Cao PH, Koh M, et al. Phytomedicine. 2025 Sep;145:157040.

Dual inhibition of FACT and RRM2 suppresses the progression of pancreatic ductal adenocarcinoma driven by the oncohistone H2BG53D, 2025

Qin T, Wan YCE, Hu S, Chen J, Zhu X, Zhou J, Chen Y, Wang X, Zheng Z, Chan LL, Wong HLX, Jin H, Han J, Li Q, Gan H, Chan KM. Cell Rep. 2025 Dec 23;44(12):116596.

MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity, 2025

Asthana P, Li L, Lu L, Wu J, Zhang S, Li N, Wong SKK, Gurung S, Zhang Y, Lin Y, Peng Y, Xu Z, Chan KM, Zhai L, Lyu A, Bian ZX, Ge X, Iyaswamy A, Li M, Su Y, et al. Cell Discov. 2025 Sep 23;11(1):76.

SARS-CoV-2 Spike Protein as a Target of the COVID-19 Vaccine Disrupts Insulin Signaling in Type 2 Diabetes, 2025

Zhai L, Zhuang M, Wong HK, Lin C, Ying H, Zhang J, Bao G, Zhang Y, Xu S, Luo J, Yuan S, Wong HLX, Bian ZX. MedComm (2020). 2025 Nov 2;6(11):e70469.

The carotenoid torularhodin alleviates NAFLD by promoting Akkermansia muciniphila-mediated adenosylcobalamin metabolism, 2025

Liu C, Zheng X, Ji J, Zhu X, Liu X, Liu H, Guo L, Ye K, Zhang S, Xu YJ, Sun X, Zhou W, Wong HLX, Tian Y, Qian H. Nat Commun. 2025 Apr 8;16(1):3338.

Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis, 2024

Guo X, Asthana P, Zhai L, Cheng KW, Gurung S, Huang J, Wu J, Zhang Y, Mahato AK, Saarma M, Ustav M, Kwan HY, Lyu A, Chan KM, Xu P, Bian ZX, Wong HLX. Nat Commun. 2024 Feb 3;15(1):1034.

Exploring the mechanism of Suxin Hugan Fang in treating ulcerative colitis based on network pharmacology, 2024

Huang Q, Peng W, Luo Q, Zhao W, Dai W, Zeng H, Wong HLX, Hu X. Sci Rep. 2024 Nov 8;14(1):27196.

Method for Diagnosing and Treating Irritable Bowel Syndrome (Patent), 2024

Bian Z (Inventor), Wong HLX (Inventor), Zhai L (Inventor), Lau JYN (Inventor). Patent. 2024 Sep 19; Priority date 2023 Feb 16, Priority No. US 18/169,926.

PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness, 2024

Liang R, Ye ZW, Qin Z, Xie Y, Yang X, Sun H, Du Q, Luo P, Tang K, Hu B, Cao J, Wong HLX, Ling GS, Chu H, Shen J, Yin F, Jin DY, Chan JFW, Yuen KY, Yuan S. Nat Commun. 2024 Mar 8;15(1):2144.

Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP, 2024

Asthana P, Wong HLX. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167081.

Synergistic anti-colorectal cancer effects of WNT974 combined with artesunate via cooperative regulation of p21, p27, and AKT, 2024

Gong RH, Chen M, Huang C, Wong HLX, Chen S, Bian Z, Chen GQ. Pharmacol Res Mod Chin Med. 2024 Sep;12:100498.

Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson's disease, 2024

Mao H, Kuang Y, Feng D, Chen X, Lu L, Xia W, Gan T, Huang W, Guo W, Yi H, Yang Y, Wu Z, Dai W, Sun H, Wu J, Zhang R, Zhang S, Lin X, Yong Y, Yang X, et al. Transl Neurodegener. 2024 Jul 24;13(1):35.

Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats, 2023

Yu L, Huang C, Yang W, Ren Z, Li L, Cheng H, Lin C, Zhai L, Ning Z, Wong HX, Han Q, Jia W, Bian Z, Zhao L. Front Pharmacol. 2023 Jan 9;13:1010484.

Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome, 2023

Zhai L, Xiao H, Lin C, Wong HLX, Lam YY, Gong M, Wu G, Ning Z, Huang C, Zhang Y, Yang C, Luo J, Zhang L, Zhao L, Zhang C, Lau JYN, Lu A, Lau LT, Jia W, Zhao L, et al. Nat Commun. 2023 Aug 17;14(1):4986.

Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis, 2023

Zhai L, Huang C, Ning Z, Zhang Y, Zhuang M, Yang W, Wang X, Wang J, Zhang L, Xiao H, Zhao L, Asthana P, Lam YY, Chow CFW, Huang JD, Yuan S, Chan KM, Yuan CS, Lau JYN, Wong HLX, et al. Cell Host Microbe. 2023 Jan 11;31(1):33-44.e5.

Body weight regulation via MT1-MMP-mediated cleavage of GFRAL, 2022

Chow CFW, Guo X, Asthana P, Zhang S, Wong SKK, Fallah S, Che S, Gurung S, Wang Z, Lee KB, Ge X, Yuan S, Xu H, Ip JPK, Jiang Z, Zhai L, Wu J, Zhang Y, Mahato AK, Saarma M, et al. Nat Metab. 2022 Feb 17;4(2):203-212.

Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin–proteasome pathway, 2022

Gong RH, Chen M, Huang C, Wong HLX, Kwan HY, Bian Z. Cell Commun Signal. 2022 Mar 19;20(1):34.

Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2, 2022

Guo X, Cao J, Cai JP, Wu J, Huang J, Asthana P, Wong SKK, Ye ZW, Gurung S, Zhang Y, Wang S, Wang Z, Ge X, Kwan HY, Lyu A, Chan KM, Wong N, Huang J, Zhou Z, Bian ZX, et al. Nat Commun. 2022 Dec 23;13:7907.

Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer's Disease: A Review, 2022

Fung TY, Iyaswamy A, Sreenivasmurthy SG, Krishnamoorthi S, Guan XJ, Zhu Z, Su CF, Liu J, Kan Y, Zhang Y, Wong HLX, Li M. Biomedicines. 2022 Mar 18;10(3):705.

MT1-MMP – A potential drug target for the management of the obesity, 2022

Asthana P, Guo X, Wong HLX. Expert Opin Ther Targets. 2022 Sep 2;26(9):761-765.

Pathogenetic Role of Gut Microbiota Shunting of Dietary Phenylalanine to Phenethylamine in Diarrhea-predominant Irritable Bowel Syndrome, 2022

Zhai L, Huang C, Ning Z, Zhang Y, Zhuang M, Yang W, Wang X, Wang J, Zhang EL, Xiao H, Zhao L, Lam YY, Chow CFW, Huang J, Yuan S, Chan KM, Yuan CS, Lau JYN, Wong HLX, Bian ZX. Gut. 2022 Sep 4;71(Suppl 2):A33-A37.

Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor, 2022

Guo X, Asthana P, Gurung S, Zhang S, Wong SKK, Fallah S, Chow CFW, Che S, Zhai L, Wang Z, Ge X, Jiang Z, Wu J, Zhang Y, Wu X, Xu K, Lin CY, Kwan HY, Lyu A, Zhou Z, et al. Nat Commun. 2022 Jun 29;13(1):3749.

Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches, 2022

Zhai L, Peng J, Zhuang M, Chang YY, Cheng KW, Ning ZW, Huang T, Lin C, Wong HLX, Lam YY, Tan HY, Xiao HT, Bian ZX. Phytomedicine. 2022 May;99:154001.

Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer, 2021

Chen M, Zhong K, Tan J, Meng MM, Liu CM, Chen B, Huang C, Wong HLX, Bian Z, Su T, Kwan HY. Clin Transl Med. 2021 Nov;11(11):e564.

Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis, 2021

Chen M, Wu HL, Wong TS, Chen B, Gong RH, Wong HLX, Xiao H, Bian Z, Kwan HY. Front Pharmacol. 2021 May 5;12:657080.

Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level, 2021

Hu X, Fatima S, Chen M, Huang T, Chen YW, Gong R, Wong HLX, Yu R, Song L, Kwan HY, Bian Z. Cell Death Dis. 2021 Nov 5;12(11):1053.

Gut-microbial metabolites, probiotics and their roles in type 2 diabetes, 2021

Zhai L, Wu J, Lam YY, Kwan HY, Bian Z, Wong HLX. Int J Mol Sci. 2021 Dec 1;22(23):12846.

Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy, 2021

Chang J, Xavier HW, Chen D, Liu Y, Li H, Bian Z. Front Pharmacol. 2021 Jul 26;12:690501.

Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism, 2021

Hu X, Fatima S, Chen M, Xu K, Huang C, Gong RH, Su T, Wong HLX, Bian Z, Kwan HY. Cell Death Dis. 2021 Aug 12;12(8):791.

Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium–Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity, 2020

Zhai L, Huang T, Xiao H, Wu PG, Lin CY, Ning ZW, Zhao L, Kwan HYA, Hu XJ, Wong HLX, Li XQ, Bian Z. Front Pharmacol. 2020 Nov 19;11:576496.

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling, 2019

Wong HLX, Qin HY, Tsang SW, Zuo X, Che S, Chow CFW, Li X, Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian ZX. Nat Commun. 2019 Dec;10:1745.

Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues, 2019

Qin HY, Wong HLX, Zang KH, Li X, Bian ZX. Life Sci. 2019 Dec 15;239:116886.

From psychology to physicality: how nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life, 2019

Chow CFW, Che S, Qin HY, Kwan HY, Bian ZX, Wong HLX. Cell Cycle. 2019 Aug 18;18(16):1824-1829.

High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner, 2019

Fatima S, Hu X, Huang C, Zhang W, Cai J, Huang M, Gong RH, Chen M, Ho AHM, Su T, Wong HLX, Bian Z, Kwan HY. Cell Death Dis. 2019 Oct;10:711.

Palmitic acid is an intracellular signaling molecule involved in disease development, 2019

Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY. Cell Mol Life Sci. 2019 Jul 15;76(13):2547-2557.

Signal transducer and activator of transcription-3 drives the high-fat diet-associated prostate cancer growth, 2019

Kwan HY, Liu B, Huang C, Fatima S, Su T, Zhao X, Ho AHM, Han Q, Hu X, Gong RH, Chen M, Wong HLX, Bian Z. Cell Death Dis. 2019 Sep 2;10(9):637.

Targeting MT1-MMP: Therapeutic Opportunities In Obesity, Type 2 Diabetes And Other Associated Diseases, 2019

Wong HLX. Conference paper. 2019 Dec 10.

Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats, 2018

Zhao L, Huang Y, Lu L, Yang W, Huang T, Lin Z, Lin C, Kwan H, Wong HLX, Chen Y, Sun S, Xie X, Fang X, Yang H, Wang J, Zhu L, Bian Z. Microbiome. 2018 Jun 14;6(1):107.

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis, 2016

Wong HLX, Jin G, Cao R, Zhang S, Cao Y, Zhou Z. Nat Commun. 2016 Mar 1;7:10824.

MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis, 2012

Chan KM, Wong HLX, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z. Dev Cell. 2012 Jun 12;22(6):1176-1190.

When MT1-MMP meets ADAMs, 2012

Wong HLX, Cao R, Jin G, Chan KM, Cao Y, Zhou Z. Cell Cycle. 2012 Aug;11(15):2793-2798.

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development, 2011

Jin G, Zhang F, Chan KM, Wong HLX, Liu B, Cheah KSE, Liu X, Mauch C, Liu D, Zhou Z. EMBO J. 2011 Jun 1;30(11):2281-2293.