Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis. 2024
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2, 2022
Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis, 2022
Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of Insulin Receptor, 2022
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling, 2019
MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis, 2016
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling in calvarial osteogenesis, 2012
Asthana P, Wong HLX. Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP. Biochim Biophys Acta Mol Basis Dis. 2024 Feb 16;1870(4):167081. doi: 10.1016/j.bbadis.2024.167081. Epub ahead of print. PMID: 38367902.
Asthana P, Guo X, Wong HLX. MT1-MMP - A potential drug target for the management of the obesity. Expert Opin Ther Targets. 2022 Sep;26(9):761-765. doi: 10.1080/14728222.2022.2147271. Epub 2022 Nov 17. PMID: 36369916.
Fung, Tsz Yan, Ashok Iyaswamy, Sravan G. Sreenivasmurthy, Senthilkumar Krishnamoorthi, Xin-Jie Guan, Zhou Zhu, Cheng-Fu Su, Jia Liu, Yuxuan Kan, Yuan Zhang, and et al. 2022. Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer's Disease: A Review Biomedicines 10, no. 3: 705.
Gong RH, Chen M, Huang C, Wong HLX, Kwan HY, Bian Z. Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin-proteasome pathway. Cell Commun Signal. 2022 Mar 19;20(1):34. doi: 10.1186/s12964-022-00834-2. PMID: 35305671; PMCID: PMC8934478.
Gong RH, Chen M, Huang C, Wong HLX, Kwan HY, Bian Z. Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin-proteasome pathway. Cell Commun Signal. 2022 Mar 19;20(1):34. doi: 10.1186/s12964-022-00834-2. PMID: 35305671; PMCID: PMC8934478.
Zhai L, Wu J, Lam YY, Kwan HY, Bian ZX, Wong HLX. Gut-Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes. Int J Mol Sci. 2021 Nov 27;22(23):12846. doi: 10.3390/ijms222312846. PMID: 34884651; PMCID: PMC8658018.
Chang J, Xavier HW, Chen D, Liu Y, Li H, Bian Z. Potential Role of Traditional Chinese Medicines by Wnt/β-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy. Front Pharmacol. 2021 Jul 26;12:690501. doi: 10.3389/fphar.2021.690501. PMID: 34381360; PMCID: PMC8350388.
Chen M, Zhong K, Tan J, Meng M, Liu CM, Chen B, Huang C, Wong HLX, Bian Z, Su T, Kwan HY. Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer. Clin Transl Med. 2021 Nov;11(11):e564. doi: 10.1002/ctm2.564. PMID: 34841696; PMCID: PMC8567042.
Hu X, Fatima S, Chen M, Huang T, Chen YW, Gong R, Wong HLX, Yu R, Song L, Kwan HY, Bian Z. Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level. Cell Death Dis. 2021 Nov 5;12(11):1053. doi: 10.1038/s41419-021-04247-w. PMID: 34741022; PMCID: PMC8571272.
Chen M, Wu HL, Wong TS, Chen B, Gong RH, Wong HLX, Xiao H, Bian Z, Kwan HY. Combination of Wogonin and Artesunate Exhibits Synergistic anti-Hepatocellular Carcinoma Effect by Increasing DNA-Damage-Inducible Alpha, Tumor Necrosis Factor α and Tumor Necrosis Factor Receptor-Associated Factor 3-mediated Apoptosis. Front Pharmacol. 2021 May 5;12:657080. doi: 10.3389/fphar.2021.657080. PMID: 34025421; PMCID: PMC8131852.
Zhai L, Huang T, Xiao HT, Wu PG, Lin CY, Ning ZW, Zhao L, Kwan HYA, Hu XJ, Wong HLX, Li XQ, Bian ZX. Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium-Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity. Front Pharmacol. 2020 Nov 19;11:576496. doi: 10.3389/fphar.2020.576496. PMID: 33658925; PMCID: PMC7919193.
Qin HY, Xavier Wong HL, Zang KH, Li X, Bian ZX. Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues. Life Sci. 2019 Dec 15;239:116886. doi: 10.1016/j.lfs.2019.116886. Epub 2019 Oct 31. PMID: 31678286.
Fatima S, Hu X, Huang C, Zhang W, Cai J, Huang M, Gong RH, Chen M, Ho AHM, Su T, Wong HLX, Bian Z, Kwan HY. High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner. Cell Death Dis. 2019 Sep 26;10(10):711. doi: 10.1038/s41419-019-1958-6. PMID: 31558710; PMCID: PMC6763436.
Kwan HY, Liu B, Huang C, Fatima S, Su T, Zhao X, Ho AHM, Han Q, Hu X, Gong RH, Chen M, Wong HLX, Bian Z. Signal transducer and activator of transcription-3 drives the high-fat diet-associated prostate cancer growth. Cell Death Dis. 2019 Sep 2;10(9):637. doi: 10.1038/s41419-019-1842-4. PMID: 31474764; PMCID: PMC6717738.
Chow CFW, Che S, Qin HY, Kwan HY, Bian ZX, Wong HLX. From psychology to physicality: how nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle. 2019 Aug;18(16):1824-1829. doi: 10.1080/15384101.2019.1637203. Epub 2019 Jul 4. PMID: 31272268; PMCID: PMC6681773.
Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY. Palmitic acid is an intracellular signaling molecule involved in disease development. Cell Mol Life Sci. 2019 Jul;76(13):2547-2557. doi: 10.1007/s00018-019-03092-7. Epub 2019 Apr 9. PMID: 30968170.
Zhao L, Huang Y, Lu L, Yang W, Huang T, Lin Z, Lin C, Kwan H, Wong HLX, Chen Y, Sun S, Xie X, Fang X, Yang H, Wang J, Zhu L, Bian Z. Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats. Microbiome. 2018 Jun 14;6(1):107. doi: 10.1186/s40168-018-0492-6. PMID: 29903041; PMCID: PMC6003035.
Jin G, Zhang F, Chan KM, Xavier Wong HL, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z. MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J. 2011 Jun 1;30(11):2281-93. doi: 10.1038/emboj.2011.136. Epub 2011 May 13. PMID: 21572390; PMCID: PMC3117651.